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Chlorhexidine is the gold standard when it comes to substantivity, which explains its superior anti-plaque effect because of its superior degree of persistence at the tooth surface (hydroxyapatite) or, more correctly, the superior persistence of its antibacterial effect (both bactericidal and bacteriostatic) at the tooth surface. 1. Prevention & treatment of gingivitis. For home use between periodontal treatment visits. 2. Minimizing plaque build up in the absence of brushing. 3. Fungal infections of the mouth: oral candidiasis, denture stomatitis. 4. Secondary bacterial infections for aphthous ulcer. 5. Rinsing & gargling for oropharyngeal viral infections.